In fact, in a most eukaryote cells, a rather large percentage of the total genome is noncoding DNA, but this varies between species. However, it is now a misnomer to call this material "junk," because the more sophisticated we become at biochemistry, we find that many do have subtle biological functions, including the transcriptional and translational regulation of certain protein-coding sequences. Researchers also belive that other noncoding sequences have a likely, but unconfirmed function, as an inference from high levels of inherited tratis and natural selection processes (Masters, 2005, 163-5).
Researchers know that the amount of genomic DNA varies widely between organisms, as does the proportion of coding and non-coding DNA within these genomes. For instance, 98% of the human genome does not encode for protein sequences, but may still have vestigial uses. There are also a number of exceptions that may be the result of evolutionary processes that allowed for primitive organisms to even exist in the more hostile environment of early earth. For instance, an Amoeba dubia has 200 times the amount of DNA than humans; the puffer fish has a genome only about 1/8 the size of the human genome, yet has a comparable number of genes, but 90% of those are non-coding. Further, about 80% of human nucleotide bases may be transcribed, but transcription does not necessarily imply function (Pennisi, 2007).
Further, research shows that non-coding DNA may have an important biological function. Studies in comparative genomics reveals that some regions of noncoding DNA are considered to be highly conserved -- sometimes millions of years -- which implies that these regions are under strong evolutionary pressure for selection of positive traits. One interesting example is that of the genomes of humans and mice, which diverged from a common ancestor about 75 million years ago. Protein-coding DNA account for only about 20% of the conserved DNA, with the remaining majority appearing in noncoding regions (Ludwig, 2002).
Further, one of the key features of biological evolution is the conservation of energy. Why would an organism carry large amounts of unnecessary molecules that require energy if there was not a reason for their existence? Noncoding DNA must influence the behavior of other coding-DNA in ways not understood, or be the result of an evolutionary necessity. Recent studies have shown that, in fact, evolution has favored those species with large amounts of noncoding DNA because some of the "junk" actually form switches that do no encode proteins, but do regulate when and where genes are expressed (Carrol, 2008).
From and evolutionary standpoint, shared sequences of apparently non-functional DNA are a major line of evidence for the idea of common descent. For instance, the Hox genes are a set of transcription factors that specify segment identity -- or whether a certain segment of the embryo will form the head, heart, abdomen, etc. It is sort of a digital body patterning, but the actual function of this gene shows tendencies as being highly conserved across long evolutionary distances. This can be demonstrated by showing that a fly can function quite well with a chicken HOX protein in place of its own. This essentially proves that, despite having lost a shared ancestor over 670 million years ago, a given Hox protein in chickens and flies are so similar that they can actually take each other's place within the overall body system. Hox is so important (conserved because it lays out the basic format of an organism) that even a single mutation in the DNA of these genes has a drastic effect on the organism, proving these genes have changed relatively little over the last several million years (Gilbert, 2000).
REFERENCES
Carrol, S.E. (2008). Regulating Evolution. Scientific American, 298(5), 60-7.
Chaisson, E. (2005, June). Early Cells. Retrieved October 2010, from Tufts University: http://www.tufts.edu/as/wright_center/cosmic_evolution/docs/text/text_bio_1.html
Gilbert, S. (2000, July). Homeotic Selector Genes. Retrieved October 2010, from National Institute of Health: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=dbio&part=A1971#A2009
Ludwig, M. (2002). Functional Evolution of NonCoding DNA. Current Opinion in Genetics and Development, 12(6), 634-39.
Masters, C. (2005). DNA and Your Body: What You Need to Know About Biotechnology. New South Wales: UNSW Press.
Pennisi, E. (2007). DNA Study Forces Rethink of What It Means to be a Gene. Science, 316(5831), 1556-7.
Walker and Jones. (2003). Genes and DNA. Sooke, BC: Kingfisher Press.
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